Losing weight isn’t easy for everyone, even with healthy eating and exercise. For people with obesity or weight-related health issues, medication can offer extra help. Understanding the types of weight loss medicine available helps you make informed decisions based on your body’s needs and health history.
When Is Prescription Weight Loss Medication Recommended?
Prescription weight loss medicine is usually given to people with a BMI of 30 or higher. It can also be considered if your BMI is 27 or more and you have health conditions like high blood pressure, diabetes, or sleep apnea. These medications are meant to be used with lifestyle changes like eating better and moving more.
Weight loss medicine is not a quick fix. It works best when paired with long-term habits. Regular follow-ups with your healthcare provider help track your progress and adjust the dose or type of medicine as needed.
7 Prescription Weight Loss Medications That Actually Work
There are different types of weight loss medicine that target appetite, metabolism, or how your body processes food. Each one has a specific purpose, and some work better for certain health conditions than others. Below are seven prescription options and who they are best suited for.
- Semaglutide (Wegovy)
Semaglutide is a weekly injection that helps control appetite by acting on hormones that affect hunger and digestion. It also slows how quickly food leaves your stomach, which keeps you feeling full longer.
This medicine is best for adults with obesity or those with type 2 diabetes. It’s especially useful if you struggle with constant cravings or overeating.
Some people may feel nausea at first, but this usually gets better with time. It can be expensive, especially without insurance, so cost is a factor to consider.
- Liraglutide (Saxenda)
Liraglutide works similarly to semaglutide but is taken daily. It helps reduce appetite and promotes feelings of fullness by slowing digestion.
It’s approved for adults and teens aged 12 and up who need support with weight loss. Daily dosing makes it easier for some people to stay consistent.
The dose is increased slowly to avoid stomach issues like nausea. Long-term success depends on continued use and support from a healthcare provider.
- Phentermine-Topiramate (Qsymia)
This combination medication suppresses appetite and makes you feel full faster. It blends two drugs: phentermine, a stimulant, and topiramate, used to treat migraines and seizures.
It’s recommended for adults without a history of heart disease or uncontrolled high blood pressure. People who struggle with constant hunger or binge eating may benefit from this option.
Because it can affect mood or sleep, regular check-ins are important. You may also need a sleep assessment if side effects affect your rest.
- Naltrexone-Bupropion (Contrave)
Contrave combines two medications that act on the brain to reduce hunger and cravings. It’s especially effective for those dealing with emotional eating or food addiction patterns.
It’s a good choice if you eat more when stressed or bored and need help staying on track. Some people also find that it helps improve their mood.
However, it may raise blood pressure and cause nausea during the first few weeks. It’s important to start with a low dose and increase gradually to avoid side effects.
- Orlistat (Xenical)
Orlistat works differently from other options. Instead of changing your hunger signals, it blocks your body from absorbing about 25% of the fat you eat.
It’s a non-stimulant choice for those who prefer a medication that doesn’t affect the brain or heart. It works best with a low-fat diet and regular physical activity.
Eating too much fat while on orlistat can lead to oily stools and gas. Taking a multivitamin is also recommended, since the medicine can reduce the absorption of some nutrients.
- Setmelanotide (Imcivree)
Setmelanotide is made for people with specific genetic conditions that lead to obesity, like POMC or LEPR deficiency. It helps regulate hunger and energy balance in the brain.
This medication is only available after genetic testing confirms you have a qualifying condition. It’s not used for general weight loss or typical obesity.
Because it targets rare issues, not everyone is eligible to use it. However, it’s a powerful tool for people with these rare disorders when other types of weight loss medicine don’t work.
- Benzphetamine (Didrex) and Diethylpropion
These older medications act as stimulants to reduce appetite. They are usually used short-term to jumpstart weight loss.
They are best for adults who need an initial boost in their weight loss plan. Doctors often prescribe them for a few weeks at a time, especially when lifestyle changes alone aren’t enough.
These medications may increase heart rate or cause jitteriness. Because they can lead to dependency, they should be taken under close medical supervision.

Things to Know Before Starting Prescription Weight Loss Medication
Before trying any types of weight loss medicine, it’s important to understand how they fit into your overall health plan. Medication is just one piece of the puzzle. Diet, movement, sleep, and mental health all play a role in long-term success.
A proper medical checkup helps determine which medicine, if any, is right for you. This includes looking at your health history, current medications, and possible risk factors.
- Get Medical Supervision: Always work with a licensed provider when starting weight loss medication. They’ll guide you on dosage, monitor side effects, and track your progress.
- Manage Expectations: Weight loss takes time and varies from person to person. Some may lose several pounds quickly, while others need more time.
- Stay Consistent: Skipping doses or stopping early reduces how well the medication works. Stick with your prescribed schedule for the best outcome.
- Know the Risks: Every medicine has possible side effects. These may include digestive issues, changes in mood, or increased heart rate depending on the drug.
- Check for Interactions: Some weight loss medicines can affect other medications you’re taking. Always share your full health history with your doctor.
- Get a Sleep Assessment: Sleep affects weight loss more than most people realize. If your medication impacts your rest, a sleep assessment can help address the issue early.
Choosing the Right Medication for Your Needs
Not all types of weight loss medicine are right for everyone. Choosing the best one depends on your medical history, lifestyle, and goals. What works well for one person may not work the same for another.
Think about your eating patterns, stress levels, and ability to follow through with treatment. Some medications need daily use, while others are weekly. Your comfort level with injections or pills will also affect your decision.
Ultimately, your healthcare provider is the best person to help you weigh the pros and cons. They’ll look at your full picture—not just your weight—and help you choose a safe and effective option.
Take Control of Your Health with HOW Clinics: Find the Right Type of Weight Loss Medicine for You
At HOW Clinics, our team helps you understand the different types of weight loss medicine and how they fit your goals. Whether you’re considering injections, appetite suppressants, or non-stimulant options, we’ll create a plan based on your body and lifestyle.
We also offer full health screenings, sleep assessments, and ongoing support to keep you on track. Book your consultation with HOW Clinics today at (519) 340-2744 and start your journey toward a healthier, more balanced life—with professional guidance every step of the way.

